Comparison with MRI
The pictures on the right show photo and MRI contrast images of a mouse with 2 implanted tumors. The second image shows a magnetic relaxometry spatial image either by itself (at left) or overlaid onto the anatomy of a mouse, clearly confirming the presence and localization of the 2 tumors. Finally, at the bottom, magnetic relaxometry images have been overlaid onto a mouse MRI image. Note that the MRI contrast image shows areas of accumulated contrast from nanoparticles not connected to cancer, while the relaxometry spatial images contain clearly defined positive signals that can be accurately located in space. We have further demonstrated that our method gives a linear signal based upon tumor cell number, whereas the MRI signal is non-linear.
Imaging of her2-targeted magnetic nanoparticles for breast cancer detection: direct comparison of SQUID-detected magnetic relaxometry and magnetic resonance. Contrast Media and Molecular Imaging. 2012:7:308-319
Photo and MRI contrast images of a mouse with 2 xenographic tumors implanted
Magnetic relaxometry spatial image and that image co-registered on the anatomy of a mouse, confirming tumors
Magnetic relaxometry images (colors) co-registered on a mouse MRI, blue and green are 95% confidence limits on location of cancer and red is from particles in the liver